At first, cells lose their ability to supply IL-2 and TNFα, which is adopted by the loss of high proliferative capacity and cytotoxic potential, and finally results in their deletion. Exhausted T cells usually point out larger levels of CD43, CD69 and inhibitory receptors combined with decrease expression of CD62L and CD127. Exhaustion can develop throughout chronic infections, sepsis and cancer. Exhausted T cells preserve their purposeful exhaustion even after repeated antigen publicity. T cell exhaustion may be triggered by several factors like persistent antigen publicity and lack of CD4 T cell help. Antigen exposure additionally has effect on the
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